Obesity and Genetics

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The European change in fat metabolism from ancient to modern times

Recently, evolutionary biologists have been looking into how changes in diet have led to human adaptations to genes that regulate fat metabolism. There are two essential genes that regulate the synthesis of vital fatty acids, fatty acid desaturase 1 and...
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Childhood weight is 35-40% inherited

A new study from the University of Sussex has found that 35-40% of a child’s BMI is inherited from their parents. For obese children this proportion rises to approximately 55-60%. The research used data from 100,000 children and their parents across...
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New potential therapeutic target receptor identified

A team of scientists from King’s College London and Imperial College London have identified a receptor called FFAR2 that may be used in the fight against obesity, publishing their study in Nature Reviews Endocrinology. They tested a high fat diet, containing...
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Hormone involved in maturation of fat cells discovered

Researchers at Stanford University have identified a hormone that is involved with the maturation of fat cells. These findings help us understand why some stem cells differentiate into fat cells. The hormone itself is called Adamts1. It is produced by...
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Genes aren’t to blame for inability to lose weight

Although individuals may be able to blame genes for weighing more, they may not be able to blame them for an inability to lose weight. This is the conclusion of a study published in the BMJ. Carriers of the FTO gene are known to be an average of 3kg heavier...
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New drug treatment for rare genetic disease

A new drug has been shown to be effective in the treatment of a rare genetic disease that leads to obesity. In a paper published in NEJM, Setmelanotide was shown to induce weight loss and reduce appetite in patients with Pro-opiomelanocortin (POMC) deficiency....
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SORLA – Controlling insulin signals and promoting obesity

SORLA is a protein that influences the balance of metabolic processes in fat tissue. An increased amount of SORLA can make cells overly sensitive to insulin, which leads them to break down less fat. A collaborative team of researchers at the Max Delbrück...
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The fatter you are, the harder it is burn fat

The fatter you are, the more your body produces a protein that inhibits the ability to burn fat. An international team of researchers have published a study in Nature Communication that suggests a protein called sLR11 acts to suppress the process of thermogenesis....
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