Obesity Care

Acute and Chronic Effects of Exercise on Appetite, Energy Intake, and Appetite-Related Hormones

The simple equation for obesity is Energy out < Energy in. The simplest way of increasing our ‘Energy out’, is to exercise more. However, the benefits of exercise extend beyond just calories, and in fact, it’s thought that exercise can improve subjective and homeostatic mediators of appetite in directions associated with enhanced meal-induced satiety. The degree to which this effect exists in an individual is highly variable and difficult to predict. This review, published in Nutrients, seeks to understand how adiposity, sex, and habitual physical activity modulate exercise-induced appetite, energy intake, and appetite-related hormone responses.

The review found that changes in perceptions of appetite, energy intake, and macronutrient composition in response to acute and chronic exercise stimuli are not modulated by levels of body adiposity or sex. However, in individuals with higher levels of habitual physical activity, they may exhibit improved sensitivity of the appetite control system through better compensatory adjustments for the energy content and density of food.

Although not conclusive, this paper draws attention to the benefits of exercise and need for an improved understanding of the individual factors that modulate appetite, appetite-related hormones, and food intake. Responses to exercise may help to explain the individual variability in body weight changes, and to facilitate the development of more efficacious weight management interventions.

A long-term maternal diet intervention to avoid the obesogenic effect in the offspring

The American Heart Association states that obesity among girls and women has generated a vicious cycle that contributes to the obesity epidemic. Studies into maternal overnutrition have found that high-fat diets in humans (which reflects the western diet), whereby the baby is exposed to over-nutrition during gestation, have increased risks of obesity, diabetes and other complications. In this study, published in The Journal of Nutritional Biochemistry, the diets of pregnant mice are varied to see whether they can prevent obesity related disease in the offspring, regardless of the weight-management of the mother.

The researchers transitioned the mice to normal fat (NF) diet 1 week, 5 weeks and 9 weeks before conception and continued this throughout gestation and lactation. After this, the offspring were given a high-fat diet for 12 weeks then sacrificed. They found that the mice whose parent had the NF diet for 9 weeks had a reduced risk of obesity, diabetes and other complications, regardless of maternal weight, suggesting a metabolic memory in the offspring that can be improved. Although the metabolic profiles of mice and humans are vastly different, the ease of access and economy of lifestyle interventions mean that a strategy to improve maternal diet for a period before conception, may be able to help prevent multi-generational obesity.

Eating faster is associated with general and abdominal obesity among Chinese children

Eating faster results in an increased rate of energy intake. However, the relationship between children’s eating speed, food intake and general abdominal adiposity is unknown, and forms the basis of this paper. A total of 50,037 Chinese children aged 7-17 years were enrolled from 7 provinces in China in 2013. Objective measurements of anthropometrics were taken and food speed was assessed by questionnaire.

There was a significant increasing trend across the slow, medium, and fast eating speed groups observed, in the prevalence of general obesity (7.2%, 10.0% and 15.9%), abdominal obesity (16.1%, 21.8%, and 29.4%) and waist-to-height ratio (WHtR) ≥ 0.5 (11.1%, 14.8%, and 22.0%). Compared with medium eating speed, fast eating speed was positively associated with obesity, abdominal obesity, and WHtR ≥ 0.5, while slow eating speed was negatively associated with these outcomes. They also found increased speed was associated with increased consumption.

Although this paper doesn’t tell us anything of the mechanism of this phenomenon, there are several biologically plausible suggestions. Such as, fast-eating leads to lower satiety and higher calorie intake, while slow-eating leads to enhanced thermic effect of food and also influences the release of gastrointestinal satiety hormones. More research should be done to see if it’s possible to change eating speed in adults, and whether this has any effect on obesity, as this could provide a simple non-invasive therapeutic target.

5 Resources All Health Professionals Should Know About

A lot of resources that are available for healthcare professionals (HCPs) are outdated, too commercial, and lack trust from the HCP community. But there are some hidden gems however, especially concerning the fields of modern health conditions, that we believe will be beneficial for those who utilise them.

1. Professr

Have you ever wanted somewhere other than Facebook to communicate with fellow health professionals?
Professr is UK based digital startup with a dedicated platform for health professionals to communicate and network with one another.

The platform is provided as a free resource to health professionals, with the intention of encouraging multidisciplinary communication and helping health professionals to support each other in an increasingly high pressure healthcare environment. This is particularly important for those who are newer to their field of practice (i.e. junior doctors), or those who work in remote or isolated conditions (i.e. outreach workers).

Professr’s forum-like features allow members to upvote and downvote answers to questions relating to healthcare, creating a repository of community-rated information. Having an opportunity to gain insights with professionals from multiple disciplines enriches the perspective of a health professional and can aid in providing better outcomes for patients.

2. CCH Toolkits

The College of Contemporary Health (CCH) is renowned as the leading global educator for obesity. They offer a range of course types including postgraduate courses and modules, short courses and on-demand courses. The short courses and on-demand courses both offer continuing professional development (CPD) credits which can be used to build professional standing, while the postgraduate options are ideal for healthcare professionals who are looking to further develop their skills and understanding in weight management and obesity care.

Besides a full range postgraduate and short courses, CCH has developed an ever growing range of toolkits. CCH toolkits are designed to be used as handouts for health professionals who can use them for themselves, or distribute to their patients.

These toolkits are easily available, open for the public, and completely free. Here you will find resources associated with health, weight management, nutrition, sleep, fatigue, mental health and many other contemporary health issues that you can refer to, and use, both personally and professionally.

The CCH Team are committed to building a comprehensive library of resources, and are constantly updating their website with new toolkits, so be sure to come back frequently or subscribe to CCH’s mailing list and have new toolkits delivered to your mailbox monthly.

You can sign up here: https://www.contemporaryhealth.co.uk/preferences

3. Conferences (Diabetes Professional Care)

Conferences are an excellent resource for health professionals that are often not utilised enough. They provide a great place to network, learn from industry leaders, and build relationships with those who share a passion for the same field of health you practise in.

Although conferences can sometimes be rather pricey to attend, some of the best ones, are in fact, free. An example of a great free-to-attend conference is Diabetes Professional Care (DPC). DPC is the is a unique, free-to-attend, CPD-accredited event for healthcare professionals (HCPs) involved in the prevention, treatment and management of diabetes, and its related conditions. Launched in 2015, DPC meets a real and increasing need for accessible education among HCPs by arming them with the skills and knowledge to provide better care for their patients.

DPC2017 attracted a record attendance of 3,235 visitors – and DPC2018 promises to be even bigger and better. So, if you’re a professional responsible for delivering diabetes care pathways at any level, it is the one event you can’t afford to miss.

This year’s DPC is on the 14th and 15th of November in London’s Kensington Olympia.

You can find more information here: https://www.diabetesprofessionalcare.com/

4. BMJ Best Practice

Healthtech is a constantly growing field and isn’t just limited to our two previously mentioned healthtech innovators such as great social platforms like Professr, and forward thinking online education institution, the College of Contemporary Health.

Instead, there has been an emergence of tools that help personal performance as a health professional and aid practice. One such tool is BMJ Best Practice.

BMJ Best Practice is ranked one of the best clinical decision support tools for health professionals worldwide. It takes you quickly and accurately to the latest evidence-based information, whenever and wherever you need it. They provide a step-by-step guidance on diagnosis, prognosis, treatment and prevention that is updated daily using robust evidence based methodology and expert opinion. Their goal is to support you in implementing good practice.

You can find more information on BMJ Best Practice here: https://bestpractice.bmj.com/info/

5. Podcasts. (Dr Chatterjee’s Feel Better, Live More)

In the field of health, there are always new developments and information that health professionals are constantly being bombarded with, and in many cases, just don’t have the time to read, watch, or catch up with. Podcasts are an excellent way of keeping up-to-date with the latest information without having to invest a huge amount of time or focus doing so. Podcasts can be listened to passively while you’re commuting, doing the washing up, or whatever mundane task you may be performing.

Our podcast pick is Dr Chatterjee’s Feel Better, Live More. It covers a range of topical issues in health, usually with highly influential guests who are experts in the area being covered. Topics have ranged from childhood obesity with Jamie Oliver, to brain nourishing foods with neuroscientist, Dr Lisa Mosconi.

The podcast is usually released on a weekly basis so it can fit into your busy schedule, perhaps your Monday morning commute.

For more information please click here: drchatterjee.com/blog/category/podcast/

Selective enzyme inhibitor reveals a novel role in fat metabolism

Cellular metabolism is a chain reaction of steps, controlled and aided by enzymes, which leads to the production of molecules that the cell requires. An important family of metabolites, called ceramides, are known to have an important role in cell signalling and apoptosis, as well as other physiological functions

In this study published in Nature, the researchers tested a new selective enzyme inhibitor called CerS1 on mice being fed a variety of different diets. They discovered that it has an important role in fat metabolism, specifically on fat deposition in mice. When they used the enzyme to inhibit metabolism, they significantly lowered fat deposition in mice, even if they were on a high-fat diet. They also found that it did not impact on glucose disposal nor insulin stimulated glucose uptake.

Although a lot more research is needed to go from mice studies to human trials, by directly affecting the cellular metabolism to prevent fat deposition, this research has demonstrated a potentially exciting new therapeutic avenue for treating obesity.

Does environment influence childhood BMI? A study of children aged 3–11

Obesity is simply caused by an imbalance in energy consumed and calories burned, however what causes this imbalance is complex and multifactorial. If enough calories are burned through physical activity, then an individual should not gain weight. Following this rationale, if an environment is more conducive to exercise then an individual is less likely to be overweight.  This argument is the basis of this paper, which explores the relationship between environment and children’s BMI.

The study included 6001 children in England, between the ages of 3 and 11. The environmental measures used looked at levels of green space, gardens, crime or multiple deprivation of a neighbourhood. Crime rates were derived from police force data, on four criminal offences; burglary, theft, criminal damage and violence. The study found that there was a moderate relationship between environment and a child’s BMI, however it is unlikely that this relationship was causal. The results instead suggest that environmental variables, such as amount of parks or recreational facilities, may be driven by selection. So those families that are less likely to have overweight children, are more likely to choose to live in greener areas. This research goes against many previous studies which suggests a strong causal link between exercise promoting environments and obesity. In light of this, future research and health policy should consider the assumption that these two are linked and that managing the environment will invariably lead to lower levels of obesity.

Obesity and loss of disease-free years owing to major non-communicable diseases

Obesity is known to be associated with an increased risk of several major non-communicable diseases including type-2 diabetes, coronary heart disease, stroke, asthma and several cancers. It was previously thought that metabolically healthy obese (MHO) individuals were at no increased risk of these conditions.  MHO is characterised by a healthy blood pressure, low cholesterol, normal insulin regulation and reasonable levels of physical fitness. However, more recent longitudinal studies have found that these individuals show a strong tendency to progress to an unhealthy obese state. What has been relatively understudied is the degree to which obesity is associated with the development of these major non-communicable conditions.

In this large study, published in The Lancet, the health data from 120,181 participants was analysed in order to determine how many disease-free years were lost to obesity. The participants were of a range of BMIs, but free of other comorbidities. They found that overweight patients lost 1 disease free-year, mildly obese patients 3-4 years and the severely obese 7-8 years compared with normal weight participants. Severe obesity was associated with the loss of 7-10 disease-free years in active and inactive individuals; current, past and never-smokers; and those of high and low socioeconomic position. The paper suggests that obesity, even in those with a healthy metabolic profile, leads to a substantial loss of disease-free years, across the social hierarchy and irrespective of lifestyle factors such as physical activity and smoking.

Contribution of maternal diabetes to visceral fat accumulation in offspring

Epidemiological studies have previously demonstrated the contribution of a genetic background of diabetes to the development of obesity. The goal of this study was to explore the contribution of parental family history of diabetes to visceral fat area. Diabetes and obesity share many overlapping risk factors and genetic architecture, with visceral fat being responsible for many of the comorbidities associated with obesity. This large study, conducted in China, recruited 1875 people, aged 20-78, with normal glucose tolerance. The recruited individuals then had an assessment of their visceral fat accumulation using MRI.

The study found that a maternal family history of diabetes was associated with visceral fat accumulation, independently in both genders. Maternal transmission had a pronounced effect on obesity and related cardiovascular risk factors, however this study does not elucidate the underlying mechanism of this visceral fat accumulation. Despite the lack of understanding of the mechanism, this data can be used to inform public health policies when trying to predict which groups will be most at risk of obesity and its related comorbidities.

Decreased Genomic Damage of Obese Patients After Bariatric Surgery

The number of bariatric operations performed globally is increasing every year. It is a very effective treatment, resulting in rapid sustained weight loss and reduction in obesity related comorbidities. However, very little is known about its impact on cancer risk. Obesity is the second biggest preventable cause of cancer after smoking. This study set out to see what effect bariatric operations had on cancer risk.

In order to assess cancer risk, peripheral blood mononuclear cells were collected from 45 obese subjects before, and at two time point after, surgery (6 and 12 months) to assess spontaneous micro-nucleus activity. Population studies have found that micronucleus frequency is correlated to cancer risk and indicates genetic damage.  

The study found that micronucleus frequency was significantly reduced in patients who had undergone bariatric surgery, which suggests that alongside it’s other key benefits, bariatric surgery has the potential to reduce the incidence of cancer.

Interactive effects of parenting behaviour and regulatory skills in toddlerhood on child weight outcomes

A known potential risk factor for childhood obesity is a low capacity for self-regulation, which is the ability to control or modulate behaviours, emotions and cognition across situations. Toddlerhood is critical period for this trait, as it is characterised by the rapid development and differentiation in regulatory capacity. In this study, the researchers investigate the relationship between inherent self-regulation and maternal behaviour.

Two aspects of maternal behaviour were assessed.These were positive responsiveness, which involves willingness to endorse the child’s choices, and gentle control, which involves attempts to change, redirect or elicit child behaviour. Toddler regulation was assessed using a variety of task based activities, questionnaires and experimenter ratings. These were then compared with BMI z scores at 4.5 years old.

This study found two significant interactions between maternal behaviours and toddler regulation in predicting BMI z score. Firstly, greater positive responsiveness during free play was significantly related to lower BMI z for toddlers with poor regulation. Secondly, that greater gentle control was associated with lower BMI z for toddlers with low self-regulation, but higher BMI z in toddlers with high self-regulation. The results suggest both parenting and toddler regulation may have important implications for child obesity.

Westernisation linked gut microbiota is associated with obesity and cardiometabolic disease

Our gut microbiota is essential to human health. However, unravelling the ways in which this microbial community correlates to health is not straightforward, due to the diversity and complexity of the organisms and the individual. Westernisation, characterised by changes in diet, reduced physical activity and increased prevalence of non-communicable disease, is associated with changes in gut microbiota.

Previous studies looking to understand gut microbiota focus on extremely different populations; usually hunter-gatherers versus urban inhabitants of industrialised countries. This study, published in Nature, instead focuses on a population of 441 Colombian adults, who are in the midst of westernisation. They found that the gut microbiota of these non-western, non-traditional Colombians forms a complex enterogradient, on which features of hunter-gatherers and citizens of industrialized nations can be identified.

In order to investigate the relationships, this paper distinguished groups based on variation in microbiota, then mapped variables relating to host health afterwards. This allowed the discovery of well-defined consortia, associated with obesity, cardiometabolic risk and metabolic pathways through which microbiota could have an impact on health. Their findings illustrate the multiple ways in which the microbiota can affect health and disease. Furthermore, it suggests that strategies to promote a healthy microbiome might be an effective means of alleviating conditions contributing to the burden of disease in Western societies.

Association between an overall maternal healthy lifestyle and the risk of obesity in offspring

Currently one in five american children are suffering obesity. With these figures growing each year, it has become a public health priority to identify modifiable risk factors for the prevention of childhood obesity. The causes of obesity are complex, however can be divided into genetic causes and lifestyle causes. These lifestyle causes often lead to rapid weight gain, suggesting that “nurture” carries more weight than “nature” in driving the current pandemic.

This paper, published in the BMJ, sought to examine the association between a healthy maternal lifestyle and the risk of developing obesity in offspring. A healthy lifestyle was characterised by healthy BMI, high quality diet, regular exercise, no smoking and light to moderate alcohol intake. Overall, it was found that a healthy lifestyle in the mother was associated with substantially lower risk of obesity in their children. If they adhered to the five low risk lifestyle factors, the children had a 75% lower risk of developing incident obesity than children of mothers who did not adhere to any of the low risk lifestyle factors.

Although this paper cannot draw any conclusions as to the mechanism of this relationship, their findings highlight maternal lifestyle choices as a potentially crucial factor in the aetiology of childhood obesity, adding weight to the argument that parent and family based interventions for reducing childhood obesity are a crucial and important target.