Obesity Care

Maternal obesity directly impacts male offspring’s lifelong health

Recent findings reveal that sons born to mothers with obesity are more likely to face a host of health challenges from birth into adulthood, including a predisposition to obesity, liver conditions, and diabetes.

This increased risk is attributed to the unique way male hormones, or androgens, interact with the developmental processes of the liver in male offspring.

A groundbreaking study spearheaded by the University of South Australia (UniSA) delves into the complex effects maternal obesity has on the foetal liver’s response to androgen signalling.

The research highlights a concerning trend: male foetuses carried by women with obesity exhibit altered liver responses to androgens, pushing them towards accelerated growth, often at the cost of their long-term health.

According to UniSA’s Dr Ashley Meakin, androgens play a pivotal role in bestowing male traits and are integral to male development. However, an excess of these hormones can lead to oversized male foetuses. This not only complicates the birthing process but can also lead to lifelong liver function issues.

In contrast, female foetuses seem to have a protective mechanism against the excess testosterone stemming from maternal obesity, effectively dampening the androgen pathway in the liver. This curbs their growth and reduces the likelihood of facing metabolic disorders in later life.

Dr Meakin notes significant gender disparities in the prevalence of metabolic disorders in adulthood, attributing a higher susceptibility to non-alcoholic fatty liver diseases and diabetes in men to maternal obesity during pregnancy, especially if the birth weight exceeds 4 kilograms.

The research team, including study lead Professor Janna Morrison, head of the Early Origins of Adult Health Research Group at UniSA, underscores the critical importance of balanced nutrition during pregnancy. They argue that achieving a “Goldilocks pregnancy” – not too little, not too much, just right – is essential for fostering the best health outcomes for offspring.

Professor Morrison warns of the long-term challenges posed by societal attitudes towards nutrition, emphasising the urgent need to combat obesity and its ripple effects from gestation through to adulthood. She advocates for early education on healthy eating habits, which can have a lasting impact, particularly during pregnancy when optimal nutrition is crucial.

In the meantime, Dr Meakin suggests that dietary supplements might offer a temporary solution to correct nutritional imbalances during pregnancy, ensuring the foetus has the best possible conditions for healthy development.

The study, published in the journal Life Sciences, forms part of a broader investigation by Professor Morrison and her colleagues into the effects of maternal nutrition – both excessive and insufficient – on the developing placenta, heart, lungs, and liver.

Comprehensive analysis shows ultra-processed foods elevate metabolic disease risks

A pivotal study published in Frontiers in Nutrition meticulously explores the connection between the intake of ultra-processed foods (UPFs) and the heightened risk of metabolic disorders.

The consumption of UPFs is often discouraged due to its potential role in fostering metabolic conditions such as type 2 diabetes mellitus (T2DM) and obesity. These conditions detrimentally impact various bodily systems by disrupting the normal breakdown and synthesis of substances during metabolism.

Although the root causes of metabolic disorders are complex and multifaceted, encompassing both genetic and environmental factors, diet emerges as a significant, modifiable environmental aspect.

Employing the NOVA food classification system, UPFs are identified as products of industrial processing, comprising extracted ingredients, additives, and minimal whole foods. Common examples include baked goods, processed snacks, sausages, and sugar-laden drinks.

Despite the established linkage between UPF consumption and metabolic diseases, critiques exist regarding the potential bias within the research findings.

This investigation conducted an umbrella review (UR), meticulously examining published systematic reviews coupled with meta-analyses to affirm the strength and validity of the association between UPF intake and the risk of metabolic diseases.

Databases such as Web of Science, PubMed, Embase, and the Cochrane Library were exhaustively searched up to July 15, 2023, without language limitations. The search also included citation tracking to identify additional relevant studies.

Exclusion criteria targeted studies focusing on laboratory and animal research, genetic polymorphisms, and those lacking specific data or quantitative analysis. Studies incorporating fewer than three original research articles were also omitted from the meta-analysis.

A thorough analysis of 13 meta-analyses was conducted, revealing a consistent association between UPF consumption and the onset of obesity and T2DM.

Notably, seven cross-sectional and numerous prospective cohort studies identified a 1.55 times increased risk of obesity with high UPF consumption, underscoring UPFs as a significant obesity risk factor. These results advocate for a reduction in UPF intake, highlighting a potential health benefit that healthcare professionals and policy makers should consider when developing dietary recommendations.

Furthermore, two meta-analyses indicated a significant link between UPF consumption and T2DM, with processed meats and sugar-sweetened beverages being particularly implicated. The consumption levels of these UPFs were closely tied to T2DM risk.

However, evidence supporting the connection between T2DM and UPF intake was weaker in some analyses and deemed insignificant among Asian populations.

Risks for non-alcoholic fatty liver disease (NAFLD), hypertension, and metabolic syndrome (MetS) were also associated with UPF consumption, though these findings were less consistent across different groups, indicating a need for further research.

This study underscores the association between UPF intake and an increased risk of metabolic diseases, especially obesity and T2DM, while suggesting the necessity for additional research on other metabolic conditions.

A key strength of this research lies in its thorough evaluation of the quality and credibility of each meta-analysis, marking it as the first UR to provide a comprehensive summary of the link between UPFs and metabolic diseases.

Limitations include the potential absence of specific data in underlying studies and the exclusion of certain studies in previous meta-analyses. Future research should expand to include other outcomes such as hyperuricemia and dyslipidemia. The study also did not account for residual confounding and measurement errors due to the absence of randomised controlled trials.

The consistency in defining UPFs was challenging, as few studies applied the NOVA classification system, and some meta-analyses included a mix of studies with and without this system, possibly leading to misclassification.

Moreover, the generalisability of these findings may be questioned, as the majority of the research was conducted in the United States, several European countries, and Brazil, suggesting a potential geographical bias in the results.

Study reveals kimchi’s role in combating obesity among South Koreans

In an insightful study featured in BMJ Open, the intricate link between the consumption of kimchi and obesity levels within the South Korean populace has been meticulously analysed. This research delves into the multifaceted relationship between diet and obesity, spotlighting the traditional Korean delicacy, kimchi, known for its low-calorie content yet high nutritional value, including an abundance of vitamins, dietary fibre, polyphenols, and probiotics.

Obesity, a burgeoning health crisis linked to a plethora of adverse health conditions such as diabetes, chronic kidney disease, cardiovascular diseases, and hyperlipidemia, has seen a steady rise in prevalence across South Korea. This trend accompanies a growing concern over abdominal obesity, further underscoring the urgency for effective public health strategies aimed at curtailing this epidemic. The escalating obesity rates have inevitably led to increased healthcare costs, highlighting the critical need for preventive measures.

Amidst growing concerns over kimchi’s contribution to dietary sodium intake, which a 2019-2020 survey pegged at 500 mg daily (accounting for 15% of total sodium consumption), the study embarked on exploring kimchi’s potential benefits. Despite the known risks associated with high sodium intake, including hypertension and obesity, previous investigations have suggested a positive correlation between fermented vegetables, such as kimchi, and reduced body weight, alongside improvements in cholesterol and blood glucose levels.

The current study leverages data from the expansive Health Examinees (HEXA) study, a part of a larger genetic and epidemiological research initiative aimed at uncovering the genetic and environmental determinants of chronic diseases in adults over 40. Initial assessments for HEXA were conducted between 2004 and 2013, with exclusions applied to individuals with a history of significant illnesses or lacking in reliable dietary or anthropometric data.

Utilising a semi-quantitative food frequency questionnaire, the researchers assessed participants’ dietary intakes over the past year, focusing on various types of kimchi, including kkakdugi, dongchimi, baechu kimchi, and others. The study defined obesity based on a body mass index (BMI) ≥ 25 kg/m^2 and abdominal obesity as a waist circumference (WC) ≥ 90 cm for men and ≥ 85 cm for women, incorporating a comprehensive questionnaire to gather additional demographic and lifestyle information.

The analysis involved categorising participants according to their kimchi intake levels and employing multivariable logistic regression to estimate the associations between kimchi consumption and obesity.

Involving 115,726 individuals, with an average age of 51.8 years and a majority being female, the study found an obesity prevalence of 28.2% overall. Notably, individuals indulging in five or more servings of kimchi daily exhibited higher weights and waist circumferences, alongside an increased likelihood of obesity and alcohol consumption.

Distinct patterns emerged between genders; men consuming significant amounts of kimchi tended to be younger, smokers, taller, and more physically active, while women with high kimchi intake were generally older, non-smokers, less active, post-menopausal, shorter, and married.

The study highlighted a nuanced relationship between kimchi consumption and obesity, indicating that moderate intake (one to three servings daily) was inversely associated with obesity risk in men. Specifically, a high intake of baechu kimchi significantly reduced the prevalence of both obesity and abdominal obesity among men, while women benefited from a moderate consumption level.

Furthermore, participants who consumed kkakdugi above the median quantity experienced lower rates of abdominal obesity, showcasing the differential impacts of various kimchi types on obesity metrics.

Despite some associations indicating higher obesity rates among those with excessive kimchi consumption, these findings were not statistically significant. The study also noted that higher kimchi intake correlated with increased consumption of proteins, carbohydrates, fats, sodium, cooked rice, and overall energy.

However, the study’s cross-sectional nature and its focus on a specific population limit the ability to draw causal connections and its applicability to broader demographics, respectively.

While this study doesn’t establish causation, it adds to the body of research supporting the inclusion of probiotic foods in the diet to promote gut microbiome diversity and subsequent weight management outcomes.

Rising bowel cancer rates in UK youth linked to obesity and alcohol consumption

A recent study has highlighted a concerning trend in the United Kingdom: increasing instances of bowel cancer among younger individuals, driven by unhealthy lifestyle choices. This alarming development is primarily attributed to factors such as obesity, excessive alcohol consumption, and a general lack of physical activity.

Traditionally diagnosed in individuals over the age of 50, bowel cancer is now increasingly affecting younger demographics. This shift coincides with a deterioration in lifestyle habits among the youth, including heightened alcohol consumption and reduced physical exercise. The research, published in the ‘Annals of Oncology‘, raises questions about the adequacy of current screening ages and calls for a re-evaluation.

The study also presents worrying findings regarding bowel cancer mortality rates in women. Unlike many other cancers, which are showing a declining death rate, bowel cancer continues to pose a significant threat to women of all ages. The comparative analysis of anticipated death rates in 2024, using 2018 as a baseline, reveals that the UK is experiencing a notably higher increase in these rates compared to other European countries like Italy, Germany, Poland, and Spain.

Specifically, the UK is facing a projected 26% increase in bowel cancer death rates among men and an even more startling 39% rise among women. These figures starkly contrast with those from other European nations, where the increases, though present, are considerably lower.

Researchers have identified a worrying trend in bowel cancer mortality, especially among the 25 to 49 age group, where rates have been climbing since around the year 2000 in both men and women. This is despite an overall decrease in colorectal cancer mortality across all age groups in past decades.

Interestingly, while the overall cancer death rates in the UK are predicted to decline among both sexes, bowel cancer remains a significant exception, particularly for women. The researchers noted that while age-standardised rates (ASRs) for bowel cancer are showing a favourable decrease for men, the same is not true for women.

Professor Carlo La Vecchia, from the University of Milan, emphasises that key contributors to this rise in young people include obesity, overweight, and associated health issues like elevated blood sugar levels and diabetes. He also points out the link between alcohol consumption and early onset bowel cancer. Countries that have seen a reduction in alcohol consumption, such as France and Italy, have not witnessed such pronounced increases in bowel cancer death rates.

Professor La Vecchia also highlights the aggressiveness of early onset bowel cancer, noting its lower survival rates compared to cases diagnosed in older individuals. He urges national governments to adopt policies promoting healthier lifestyles, including increased physical activity and reduced obesity and alcohol consumption. Furthermore, he advocates for the lowering of the age threshold for bowel cancer screening to 45 years.

The World Cancer Research Fund has labelled these findings as “alarming”, acknowledging the increasing exposure of young people to cancer risk factors from an early age. Dr Panagiota Mitrou, the director of research at the WCRF, underscores the importance of addressing these risk factors early on.

In England, bowel cancer screening is currently offered to individuals aged 60 to 74, with plans to expand the programme to those aged 50 to 59. However, there is a call for further improvements in diagnosis, treatment, and survival rates. Former national cancer director, Professor Sir Mike Richards, suggests adjusting the sensitivity threshold for the FIT stool test to enhance early detection.

Responding to these concerns, a spokesperson for the Department of Health and Social Care emphasised the role of the independent UK National Screening Committee in determining the age cohorts for screening, balancing the benefits against potential harms such as overdiagnosis. They also highlighted the government’s commitment to promoting healthier food choices and tackling obesity, acknowledging its significant impact on the NHS and its contribution to a range of serious diseases.

Adolescent stress linked to adult obesity and hypertension

Recent research indicates a strong correlation between high stress levels experienced during adolescence and the subsequent development of cardiometabolic risk factors, such as obesity and hypertension, in adulthood.

Published in the Journal of the American Heart Association, this study underscores the necessity of implementing stress management techniques from an early age. These strategies are vital in reducing the likelihood of health issues later in life, including heart disease and Type 2 diabetes.

Dr. Fangqi Guo, the lead author of the study and a postdoctoral research fellow at the University of Southern California’s Keck School of Medicine, emphasises the significance of understanding how stress perceived from childhood impacts the escalation of cardiometabolic risk factors in young adults. Dr. Guo’s findings reveal that long-term stress perception significantly influences various cardiometabolic aspects such as fat distribution, vascular health, and obesity. He stresses the importance of adopting stress management practices during adolescence to safeguard health.

Cardiometabolic risk factors, encompassing obesity, Type 2 diabetes or prediabetes, high cholesterol, and hypertension, often co-occur and are major contributors to cardiovascular disease. In 2020, cardiometabolic diseases, including cardiovascular conditions and Type 2 diabetes, were leading chronic health issues in the U.S., accounting for approximately 25% of all deaths, as per the American Heart Association.

The American Heart Association’s 2017 report highlighted that childhood adversities have long-term effects on cardiometabolic health. In recent decades, perceived stress has also been increasingly recognised as a contributing factor to cardiometabolic health problems.

In this new investigation, researchers analysed data from 276 individuals participating in the Southern California Children’s Health Study. The participants, initially enrolled by their parents between 2003 and 2014 at an average age of six, underwent health assessments during adolescence and as young adults from 2018 to 2021. Their average ages during these assessments were 13 and 24 years, respectively.

Each assessment included responses to a four-item Perceived Stress Scale, a widely utilised method for assessing stress-related feelings and thoughts over the previous month. For the youngest participants, stress levels were reported by their parents. The participants were then categorised into four groups based on their stress patterns: consistently high, decreasing, increasing, and consistently low.

The study’s evaluation of cardiometabolic health involved various health measurements, such as blood pressure and weight. Researchers also examined neck artery thickness to assess blood flow, haemoglobin A1C levels to determine diabetes status, and body fat percentage, with a focus on abdominal fat, a known risk factor for cardiovascular disease and Type 2 diabetes.

Participants who reported higher stress levels from their teenage years into adulthood were more prone to high blood pressure, increased total body fat, more abdominal fat, poorer vascular health, and a higher risk of obesity than those who experienced lower stress levels.

Dr. Guo expressed surprise at the consistency of the association between perceived stress patterns and various risk factors. He advocates for healthcare professionals to incorporate the Perceived Stress Scale in clinical assessments, allowing for early identification and treatment of individuals with elevated stress levels.

Losing weight through dance could beat conventional workouts

Traditional exercise routines, often recommended for shedding weight, can pose challenges in maintaining enthusiasm and commitment. Their repetitive and solitary nature, coupled with the physical exertion required, can make them less appealing over time.

Contrastingly, dancing emerges as a potent alternative for weight loss, according to recent research findings. Its inherent enjoyment and the opportunity for social engagement it provides set it apart from conventional exercise forms.

A meta-analysis examining 10 studies focusing on dance’s impact on individuals with overweight and obesity revealed significant health benefits. Regular dancers demonstrated marked improvements in body mass index (BMI), waist circumference, body fat percentage, and total fat loss, compared to non-dancers. These findings were published in the journal PLOS ONE.

The studies encompassed a variety of dance styles, including step-aerobic, cheerleading, creative, Zumba, bhangra, traditional, dance video games, square dance, simplified dance, and aerobic fitness dance. The frequency of dance sessions varied, with most participants dancing three times a week, except for square dancers (five times a week) and bhangra dancers (twice a week). Session durations ranged from 40 to 90 minutes, and the studies lasted from four weeks to one year.

Adherence to an exercise program is crucial for its success, and dancing’s entertainment value might significantly enhance this adherence. Dr. Jagdish Khubchandani, a public health professor at New Mexico State University not involved in the study, highlighted the motivational challenges of traditional exercises, often perceived as arduous and demanding in terms of time, physical effort, and financial resources.

Stephanie Escobedo, founder of Through the Body, a dance and fitness company, and not a participant in the research, echoed this sentiment. She emphasised the importance of finding an enjoyable exercise form for consistent engagement.

Dr. Menka Gupta, a functional medicine doctor at NutraNourish, remarked on the dance’s dual physical and mental health benefits. Beyond improving BMI, dance activities can elevate mood, reduce stress, and enhance sleep quality, thanks to the dopamine release associated with pleasure.

Dr. Khubchandani also referenced studies indicating dancing’s potential to enhance executive function, offering both physical and psychological advantages.

When it comes to choosing the most beneficial dance form, Dr. Gupta advises selecting one that resonates personally, ensuring long-term commitment and consistency. For older individuals or those preferring lower intensity, she recommends ballroom dancing for its social, balance, posture, and cardiovascular benefits.

Dr. Gupta particularly praises Zumba for its mental sharpness benefits, incorporating high-intensity interval training that fosters cognitive skills like decision-making and spatial recognition.

Escobedo supports the health benefits of various dance forms, highlighting ballet for muscle strength, balance, posture, and cardio endurance, and modern/contemporary dance for agility and core strength. She notes that popular cardio dance classes can contribute significantly to weight loss and overall fitness, offering a more enjoyable alternative to routine exercises.

Finally, Dr. Gupta stresses the emotional connection aspect of dance, sharing her personal preference for Zumba and Bollywood dancing, which evoke nostalgic childhood memories and connections.

In summary, dance not only serves as an effective exercise alternative for weight management but also offers diverse physical, mental, and emotional benefits, making it a comprehensive fitness choice.

Curbing fruit juice intake in childhood may reduce obesity risk, research indicates

Recent research indicates that reducing the consumption of 100% fruit juice in children could be a key strategy in addressing the growing concern of childhood obesity, especially in younger age groups.

Published in the journal JAMA Pediatrics, this study sheds light on a significant issue: children who have overweight or obesity are more likely to maintain this status into adulthood. The researchers, therefore, advocate for limiting fruit juice intake to avoid excess calorie consumption and subsequent weight gain.

A team from the University of Toronto in Canada spearheaded the research, analysing data from 42 previous studies to explore the relationship between drinking 100% fruit juice and weight gain in both children and adults. While the link with adult weight gain requires further exploration, the team observed a definitive correlation between juice consumption and weight gain in children.

The study defined 100% fruit juice as a drink with no added sugar, with a standard serving being 8 ounces. The researchers evaluated data for approximately 46,000 children aged between 1 and 15 years. Their findings pointed to a clear association between each additional serving of 100% fruit juice and an increase in body mass index (BMI), a standard metric for determining overweight and obesity status. The team highlighted that, unlike whole fruits, juice lacks significant fibre, potentially leading to high calorie intake without a corresponding feeling of fullness.

The American Academy of Pediatrics has set guidelines advising against fruit juice for infants under one year and recommending a daily limit of 4 ounces as part of a meal for toddlers and young children. For children aged 1 to 6 years, the intake should not exceed 6 ounces per day.

On its website, the Academy emphasises, “Fruit juice offers no nutritional benefits over whole fruit,” pointing out that whole fruits also contain fibre and other essential nutrients. It advises against giving fruit juice at bedtime and cautions against its use in managing dehydration or diarrhoea.

The urgency of addressing childhood overweight and obesity is underscored by alarming statistics from the U.S., where 1 in 5 children aged 2 to 19 years have obesity. Obesity in childhood carries the risk of serious health issues such as high blood pressure, high cholesterol, type 2 diabetes, asthma, sleep apnea, and joint problems, according to the CDC.

The study observed that children consuming fruit juice gained more weight than those drinking zero-calorie beverages, like water. This weight gain was most pronounced in children aged 8 years and younger when compared to their peers consuming non-caloric drinks.

The types of juice consumed included pomegranate, berry, tart cherry, apple, citrus, and grape, with no noticeable differences in BMI impact based on juice type. The researchers suggested that weight gain could be attributed to the high liquid calorie content in fruit juice and the rapid absorption of fructose, which can affect liver function and cholesterol levels.

In conclusion, the study supports public health recommendations to limit the consumption of 100% fruit juice as a preventative measure against overweight and obesity in children.

Excessive school holiday downtime linked to rising health concerns in children

The extended school holidays, a period of relaxation and rest for educators and students alike, may be inadvertently contributing to health issues in children. Recent research highlights a worrying trend of increased weight gain during these leisure times, particularly among children.

In Australia, the prevalence of children and teenagers with overweight or obesity stands at one in four, reflecting a global issue where over 124 million children and adolescents have obesity. These alarming figures have spurred governments, educational institutions, and communities to advocate for enhanced physical activity and healthier eating habits among the younger demographic.

The groundbreaking ‘Life on Holidays‘ study, spearheaded by the University of South Australia’s Alliance for Research in Exercise, Nutrition and Activity team, is the first to explore this phenomenon outside the United States. It specifically examined the impact of holiday periods on children’s fitness levels and body composition.

The study’s findings revealed a concerning pattern: children’s body fat accumulates more rapidly during school holidays than during academic terms. Notably, children in Years 4 and 5 exhibited a decrease in physical activity and an increase in sedentary behaviours during their holidays.

Key observations included children sleeping an average of 12 minutes less, engaging in 12 fewer minutes of physical activity daily, and spending an additional 70 minutes on screens each day during holiday periods. Consequently, there was a marked acceleration in body fat accumulation and a more pronounced decline in aerobic fitness compared to term time.

Professor Tim Olds, lead researcher from UniSA, suggests that promoting physical activities during school holidays could be crucial in combating these negative health trends. He notes that while children and their parents rightly deserve holiday downtime, the lifestyle shift during these periods often negatively impacts children’s health.

“On school holidays, kids are significantly less active than when they’re at school, leading to higher body fat percentages and lower levels of fitness,” Professor Olds remarked. He expressed concern over the rapid rate of weight gain and fitness loss during holidays, pointing out the potential long-term health risks such as cardiovascular disease and Type 2 diabetes.

The study, which spanned two years, focused on children aged 9-10 years and involved over 150 participants. Data were collected at the start and end of Terms 1 and 4 across Grades 4 and 5.

Co-researcher Dr Dot Dumuid highlighted that the unstructured nature of school holidays contributes significantly to these trends. She pointed out that children have unrestricted access to food and are prone to increased screen time due to the lack of structured activities.

Dr Dumuid contrasted this with the structured environment of school days, where meals are planned, and physical education lessons and playtimes are scheduled. She suggested that adopting American-style summer camps and holiday programs could be an effective way to address the issue in Australia. These programs, she noted, have been successful in providing children with physical activities in a more structured setting.

“Summer camps and holiday programs have shown positive results in America and could offer a valuable solution during Australian holidays,” Dr Dumuid said. She emphasised the need for a balance between leisure and physical activity, questioning the reliance on devices and TV for child care at the expense of children’s health.

The study underlines the importance of finding a healthy balance between relaxation and physical activity during school holidays. As societies grapple with increasing rates of childhood obesity and associated health problems, initiatives like summer camps and structured holiday programs could play a pivotal role in ensuring the health and well-being of the younger generation.

Study highlights obesity’s role in blood condition leading to multiple myeloma blood cancer

The possible interplay between lifestyle factors such as smoking, insufficient sleep, and obesity, and their influence on a blood condition that can lead to a specific type of blood cancer, warrants further investigation, according to experts.

Recent findings published in “Blood Advances” suggest that certain modifiable risk factors, notably smoking and obesity, might elevate the risk of developing monoclonal gammopathy of undetermined significance (MGUS). This condition often precedes multiple myeloma, a form of blood cancer.

Dr. David Lee, an internal medicine resident at Massachusetts General Hospital and co-author of the study, emphasised the urgency of this research. He noted that despite significant advancements in multiple myeloma treatments, it remains incurable and is often diagnosed after considerable damage to the patient’s organs. He added, “Our research group is focused on investigating risk factors and aetiology of MGUS to better understand who may be at increased risk for developing MGUS and its progression to multiple myeloma.”

MGUS is characterised by abnormally high levels of a protein called M protein in the blood. While in most instances MGUS does not cause problems, there is an annual 1% risk of progression from MGUS to myeloma, a cancer affecting plasma cells.

Myeloma results in an accumulation of a type of white blood cell in the bone marrow, leading to tumour formation throughout the bones. The most significant risk factor for developing myeloma is age, particularly affecting those over 45. The disease is more prevalent in men and is twice as likely to occur in black individuals compared to white individuals. Furthermore, having overweight or obesity has been identified as a risk factor for myeloma.

Dr. Brian Durie, Chief Scientific Officer of the International Myeloma Foundation and a haematologist and oncologist at Cedars-Sinai Medical Center, who was not part of the study, highlighted a known correlation between MGUS, myeloma, and obesity. He explained, “There’s also a correlation between obesity and a lot of other things, other kinds of cancer, other kinds of issues with your immune system.”

The study indicated that obesity might be associated with a 73% higher likelihood of having MGUS compared to those without obesity. However, the researchers cautioned that while there is a notable connection, it does not definitively prove causation.

Dr. Gary Schiller, a clinical investigator in multiple myeloma and hematologic malignancies at the University of California Los Angeles, also not involved in the study, suggested alternative explanations for the presence of MGUS. He explained that MGUS is relatively common, especially in older populations, and its occurrence might coincide with other factors like increased body mass index and reduced sleep quality. Schiller cautioned against hastily interpreting these associations as causal relationships.

Schiller and others have investigated the influence of obesity on the progression of MGUS, exploring theories involving hormones with anti-inflammatory properties that might be deficient in individuals who have overweight. However, he asserts that the current evidence does not firmly support these hypotheses.

The authors of the study believe their findings could be instrumental in guiding future research into the role of modifiable risk factors in cancer risk. Lee stressed the importance of understanding the relationship between MGUS and these risk factors to develop effective preventative health strategies against diseases like multiple myeloma.

Durie pointed out the current lack of sufficient data to confirm that lifestyle modifications in response to these risk factors would significantly impact MGUS or myeloma outcomes. Nonetheless, he mentioned animal studies that suggest this area is worth future exploration.

The potential of modifiable risk factors in influencing health outcomes is significant, according to Durie. He suggested that efforts to reduce obesity could potentially improve outcomes for patients, emphasising the personal relevance and potential impact of such changes.

Both Durie and Schiller advise individuals with obesity and other risk factors not to be overly concerned about developing MGUS or myeloma. Durie noted, “The vast majority of patients with MGUS will never develop myeloma.” He stressed that for many, the risk of progression is low, and they are more likely to succumb to unrelated causes.

Schiller echoed these sentiments, highlighting the immediate and more pressing health risks associated with obesity, such as hypertension, diabetes, and cardiovascular diseases. He argued that these more immediate health concerns should take precedence over the potential risk of MGUS in the context of obesity.

Study shows early breastfeeding mitigates child obesity, regardless of maternal weight

A recent study funded by the Environmental influences on Child Health Outcomes (ECHO) Program at the National Institutes of Health has revealed a significant correlation between early breastfeeding and reduced childhood obesity risks. This relationship holds true irrespective of the mother’s pre-pregnancy body mass index (BMI).

The ECHO Cohort study delved into the impact of breastfeeding practices in women who had overweight or obesity before pregnancy and its influence on their children’s BMIz scores. BMIz scores are used to compare a child’s height and weight against their peers, whereas BMI assesses body weight relative to height.

The research discovered that any consistent breastfeeding during the first three months of an infant’s life was linked with lower BMIz scores at ages 2 to 6, regardless of the mother’s pre-pregnancy BMI. This association was particularly pronounced in children whose mothers had obesity before pregnancy, compared to those whose mothers were merely overweight.

Dr. Gayle Shipp from Michigan State University, who led the study, emphasised the importance of each additional month of breastfeeding, whether exclusive or combined with other foods, in contributing to lower childhood weights. This effect was notably significant for mothers who had overweight or obesity before pregnancy.

The study analysed data from 8,134 mother-child pairs across 21 sites in 16 states and Puerto Rico. It examined BMI and BMIz scores obtained from study visits, medical records, or self-reported information. The research particularly focused on two aspects of breastfeeding: whether the mother ever breastfed and if she was exclusively breastfeeding at three months. The definition of continuous breastfeeding included any breastfeeding duration with the allowance of formula or other food, and the duration of exclusive breastfeeding without formula feeding or other food.

The study found that exclusive breastfeeding at three months was linked to a lower child BMIz score primarily among women with a normal pre-pregnancy BMI. Each additional month of either any or exclusive breastfeeding correlated with a significantly lower child BMIz score, especially for mothers who had overweight or obesity before pregnancy.
Dr. Shipp highlighted the significance of this research for health professionals, suggesting it as an opportunity to promote breastfeeding among all women, particularly those with obesity. The study’s findings have been published in the journal Pediatrics.

Fasting regimen proves effective against obesity-induced cognitive decline

Researchers have recently explored the beneficial effects of intermittent fasting (IF) on neuroinflammation and cognitive decline in a study published in Nutrients. They focused on mice subjected to a high-fat diet (HFD) and examined the impacts of IF on brain health, particularly in the context of diabetic encephalopathy.

Obesity and type 2 diabetes (T2D) are known for their adverse effects on cognitive functions, including memory impairment. These conditions often lead to increased permeability of the blood-brain barrier (BBB), worsening neuroinflammation and memory issues. The disruption in the hippocampal BBB is now seen as an early indicator of diabetes-related cognitive decline.

The study highlighted the role of two proteins, lipocalin-2 (LCN2) and galectin-3 (GAL3), in obesity and T2D-related chronic inflammation. These proteins are believed to be involved in activating harmful immune responses in the diabetic brain through BBB leakage.

The researchers used a mouse model to understand how chronic IF could counteract neuroinflammation caused by LCN2 and GAL3, as well as reduce adipose tissue inflammation. Mice were divided into three groups: normal diet, high-fat diet, and high-fat diet followed by intermittent fasting. The IF group first received an HFD for eight weeks, followed by a regimen of alternating fasting for 22 weeks.

Various tests were conducted, including EchoMRI for body fat measurement, insulin and glucose tolerance tests, and enzyme-linked immunosorbent assay (ELISA) for assessing serum protein levels. Additionally, apoptosis in white adipose tissues (WATs) was measured using the TUNEL assay, and the extent of BBB leakage in the hippocampus was also examined.

The study revealed that mice on a high-fat diet showed increased body weight, body fat, impaired glucose tolerance, and adipocyte death, alongside elevated levels of LCN2 and GAL3. However, intermittent fasting led to significant weight loss, improved insulin resistance, and reduced inflammation in the adipose tissue. This intervention also decreased serum levels of LCN2 and GAL3, reducing BBB leakage, neuroinflammation, and memory deficits.

In conclusion, the study posits that IF could be an effective alternative to continuous caloric restriction. It may improve insulin resistance, reduce adipose tissue inflammation, and mitigate metabolic dysfunctions in obesity and T2D, thereby protecting against cognitive impairment and memory deficits. The findings open new avenues for research into IF as a therapeutic strategy for managing obesity and T2D-related brain health issues.

Study confirms light exercise effectively counters childhood obesity

Childhood obesity, a growing concern worldwide, might have a surprisingly straightforward solution: light exercise. Recent research led by an international team of scientists from the Universities of Exeter, Eastern Finland, Bristol, and Colorado, underscores the profound impact of light physical activity in combating the rise of obesity in children.

Drawing from the University of Bristol’s Children of the 90s study, the research tracked 6,059 children (53% female) from age 11 to 24. Amid global reports revealing a worrying trend of inactivity among adolescents — with over 80% failing to meet the World Health Organization’s guidelines for daily physical activity — the study presents an urgent narrative. The lack of exercise is anticipated to contribute to 500 million new cases of noncommunicable diseases by 2030, costing an estimated $23 million annually.

What’s striking about the study is the revelation that light physical activity, rather than moderate-to-vigorous exertion, plays a crucial role in reducing fat mass gain in youth. Dr. Andrew Agbaje of the University of Exeter, a key contributor to the study, emphasises the overlooked benefits of light physical activities like walking, household chores, and leisurely swimming. He suggests shifting public health messages from an emphasis on 60 minutes of moderate-to-vigorous activity to encouraging at least three hours of light activity daily.

Participants were observed over 13 years, with physical activity levels and health markers meticulously monitored using waist-worn accelerometers and dual-energy X-ray absorptiometry. The results were startling: each additional minute of sedentary behaviour correlated with a 1.3-gram increase in total body fat mass. In contrast, each minute of light physical activity corresponded to a 3.6-gram decrease in total body fat mass, amounting to a significant reduction of 950 grams to 1.5 kilograms over the study period.

In comparison, moderate-to-vigorous physical activity showed a minimal effect, reducing total body fat mass by only about 0.7 to 1.7 percent. This finding challenges the prevailing public health guidelines, which predominantly advocate for higher-intensity exercise.
The study, published in Nature Communications, calls for a reevaluation of health guidelines and policy statements, urging public health experts, policymakers, and parents alike to promote light physical activity as a key strategy in preventing childhood obesity. As Dr. Agbaje concludes, sustaining light physical activity can be the much-needed antidote to the detrimental effects of a sedentary lifestyle in young populations.