How Physiological Changes Associated with Obesity Affect Drug Metabolism
Obesity is known to have a significant impact on many organ systems that are crucial in drug metabolism. As the prevalence of obesity continues to rise, clinicians are being challenged with the problem of dosing in the extreme overweight population. This review article discusses the different physiological changes associated with obesity and how they affect absorption, distribution, drug...Read More
Famine Exposure During Early Life May Lead to an Increased BMI in Adulthood
It has been previously reported in epidemiologic studies that famine exposure during early life is associated with overweight or obesity in adulthood. In this systematic review and meta-analysis of 20 studies, this paper set out to determine whether exposure to famine in early-life had any association with overweight or obesity in later life. This study was conducted according to the Cochrane...Read More
Efficacy, Safety, and Mechanisms Of Herbal Medicines Used In The Treatment Of Obesity: A Protocol For Systematic Review
There is a huge amount of conflicting evidence over the potential efficacy of herbal remedies for the treatment of obesity. Although several systematic reviews have been conducted, the market is saturated with poorly evidenced claims, and a huge number of different remedies. This study sets out a protocol for a comprehensive systematic review into herbal remedies and their efficacy at treating...Read More
Cardiorespiratory fitness as a Determinant Factor for the 30% of Obese Individuals That are Metabolically Healthy
Previous studies have shown that individuals can be obese and metabolically healthy, or of normal weight with an unhealthy metabolic profile. The metabolically healthy obese (MHO) phenotype currently represents 30% of obese individuals. However, major studies have so far failed to consider the possible impact of cardiorespiratory fitness on metabolic health. MHO individuals are characterised...Read More
The Effectiveness of a School Intervention Program. A Panacea against Obesity?
A large randomised controlled trial was conducted in the West Midlands, looking into the effectiveness of a school and family based healthy lifestyle programme, in comparison to usual practice. 1,467 year 1 pupils aged 5 to 6 years (control, 778 pupils), were randomised into the study, with follow-ups at 15 months and 30 months. The intervention consisted of encouraging healthy eating and...Read More
Junk Food Advertising: How Much is Too Much?
Last week saw the implementation of the “sugar tax.” It is one of the first big government initiatives here in the UK aimed specifically at dealing with the obesity epidemic with the hope of improving public health. Despite this initial effort from the government, many are calling for even more action to be taken with some pointing their fingers squarely at the advertising industry. It’s...Read More